4-Chloroquinazoline → HCID 25105793, compound

HRID 1675352Notes

Reaction equation

HRID 1675352 reaction equation
[CH:1]1([CH2:4][NH:5][C:6]([C:8]2[S:12][C:11]([N:13]3[CH2:20][C:19]4[CH2:18][NH:17][CH2:16][C:15]=4[CH2:14]3)=[N:10][CH:9]=2)=[O:7])[CH2:3][CH2:2]1.FC(F)(F)C([O-])=O.Cl[C:29]1[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[N:32]=[CH:31][N:30]=1>>[CH:1]1([CH2:4][NH:5][C:6]([C:8]2[S:12][C:11]([N:13]3[CH2:14][C:15]4[CH2:16][N:17]([C:29]5[C:38]6[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=6)[N:32]=[CH:31][N:30]=5)[CH2:18][C:19]=4[CH2:20]3)=[N:10][CH:9]=2)=[O:7])[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 788644-ChloroquinazolineHCID 84468TrifluoroacetateHCID 67350667HCID 67350667, compound

Product 1

HCID 25105793HCID 25105793, compound

Procedure

N-(Cyclopropylmethyl)-2-(3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)thiazole-5-carboxamide, trifluoroacetate (106 mg, 0.26 mmol) was reacted with 4-chloroquinazoline analogously to example 5. M+H+: 419.15.

Sources & evidence

ORD record
ord-47fd8cf3e3a048cc939929569423b674
Source dataset
uspto-grants-2011_08
Patent number
US08003677B2

Reaction notes

Loading…