Trifluoroacetate → HCID 25105812, compound

HRID 1675355Notes

Reaction equation

HRID 1675355 reaction equation
[CH3:1][CH:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[S:12][C:11]([N:13]2[CH2:20][C:19]3[CH2:18][NH:17][CH2:16][C:15]=3[CH2:14]2)=[N:10][CH:9]=1)=[O:7].FC(F)(F)C([O-])=O.[Br:29][C:30]1[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][C:31]=1[C:32](O)=[O:33].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>>[CH3:1][CH:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[S:12][C:11]([N:13]2[CH2:14][C:15]3[CH2:16][N:17]([C:32](=[O:33])[C:31]4[CH:35]=[C:36]([O:39][CH3:40])[CH:37]=[CH:38][C:30]=4[Br:29])[CH2:18][C:19]=3[CH2:20]2)=[N:10][CH:9]=1)=[O:7]

Participants

5

Reactant 4

HCID 84468TrifluoroacetateHCID 899062-Bromo-5-methoxybenzoic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 58459774HCID 58459774, compound

Product 1

HCID 25105812HCID 25105812, compound

Procedure

N-(3-Methylbutyl)-2-(3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)thiazole-5-carboxamide, trifluoroacetate (43.8 mg, 0.1 mmol) was reacted with 2-bromo-5-methoxybenzoic acid after activation with HATU analogously to example 3f. M+H+: 519.15.

Sources & evidence

ORD record
ord-1166a5615b024a62bee083464eccb174
Source dataset
uspto-grants-2011_08
Patent number
US08003677B2

Reaction notes

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