Trifluoroacetate → HCID 25105813, compound

HRID 1675356Notes

Reaction equation

HRID 1675356 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][NH:10][C:11]([C:13]2[S:17][C:16]([N:18]3[CH2:25][C:24]4[CH2:23][NH:22][CH2:21][C:20]=4[CH2:19]3)=[N:15][CH:14]=2)=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C([O-])=O.[Br:33][C:34]1[CH:42]=[CH:41][C:40]([O:43][CH3:44])=[CH:39][C:35]=1[C:36](O)=[O:37].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>>[C:1]1([CH2:7][CH2:8][CH2:9][NH:10][C:11]([C:13]2[S:17][C:16]([N:18]3[CH2:25][C:24]4[CH2:23][N:22]([C:36](=[O:37])[C:35]5[CH:39]=[C:40]([O:43][CH3:44])[CH:41]=[CH:42][C:34]=5[Br:33])[CH2:21][C:20]=4[CH2:19]3)=[N:15][CH:14]=2)=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 4

HCID 84468TrifluoroacetateHCID 899062-Bromo-5-methoxybenzoic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 58459775HCID 58459775, compound

Product 1

HCID 25105813HCID 25105813, compound

Procedure

N-(3-Phenylpropyl)-2-(3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)thiazole-5-carboxamide, trifluoroacetate (44.6 mg, 0.095 mmol) was reacted with 2-bromo-5-methoxybenzoic acid after activation with HATU analogously to example 3f. M+H+: 567.17.

Sources & evidence

ORD record
ord-c84f06f40ea7426cbc3476ab3ddc6323
Source dataset
uspto-grants-2011_08
Patent number
US08003677B2

Reaction notes

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