HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1,3-Thiazol-2-yl)methanamine hydrochloride → N-Thiazol-2-ylmethyl-6-[5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo-[3,4-c]pyrrol-2-yl]nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1,3-Thiazol-2-yl)methanamine hydrochloride | HCID 42614216 | — |
| Reactant | 6-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]nicotinic acid | HCID 58459784 | — |
| Product | N-Thiazol-2-ylmethyl-6-[5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo-[3,4-c]pyrrol-2-yl]nicotinamide | HCID 25105831 | 28% |
Reaction Steps
6-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]nicotinic acid (54 mg, 0.134 mmol) was reacted with C-thiazol-2-ylmethylamine, hydrochloride analogously to example 3d. Yield: 28%, M+H+: 500.22.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003677B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-e9fa320f066b4fe08c261f424a13af74 |
| Source note | uspto-grants-2011_08 |