Cyclopropanemethanamine → HCID 25105833, compound

HRID 1675361Notes

Reaction equation

HRID 1675361 reaction equation
[F:1][C:2]([F:29])([F:28])[C:3]1[CH:27]=[CH:26][CH:25]=[CH:24][C:4]=1[C:5]([N:7]1[CH2:11][C:10]2[CH2:12][N:13]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][N:16]=3)[CH2:14][C:9]=2[CH2:8]1)=[O:6].[CH:30]1([CH2:33][NH2:34])[CH2:32][CH2:31]1>>[CH:30]1([CH2:33][NH:34][C:19](=[O:21])[C:18]2[CH:22]=[CH:23][C:15]([N:13]3[CH2:12][C:10]4[CH2:11][N:7]([C:5](=[O:6])[C:4]5[CH:24]=[CH:25][CH:26]=[CH:27][C:3]=5[C:2]([F:1])([F:28])[F:29])[CH2:8][C:9]=4[CH2:14]3)=[N:16][CH:17]=2)[CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 75646CyclopropanemethanamineHCID 584597846-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]nicotinic acid

Product 1

HCID 25105833HCID 25105833, compoundYield 77%

Procedure

6-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]nicotinic acid (54 mg, 0.134 mmol) was reacted with C-cyclopropylmethylamine analogously to example 3d. Yield: 77%, M+H+: 457.26.

Sources & evidence

ORD record
ord-df89b4e59fd44e2c9af56a4cd1a4ff68
Source dataset
uspto-grants-2011_08
Patent number
US08003677B2

Reaction notes

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