Trifluoroacetate → HCID 25105851, compound

HRID 1675362Notes

Reaction equation

HRID 1675362 reaction equation
[OH:1][CH:2]([CH2:22][CH3:23])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[N:9]=[N:10][C:11]([N:14]2[CH2:21][C:20]3[CH2:19][NH:18][CH2:17][C:16]=3[CH2:15]2)=[CH:12][CH:13]=1)=[O:7].FC(F)(F)C([O-])=O.[Br:31][C:32]1[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[CH:37][C:33]=1[C:34](O)=[O:35].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>>[OH:1][CH:2]([CH2:22][CH3:23])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[N:9]=[N:10][C:11]([N:14]2[CH2:21][C:20]3[CH2:19][N:18]([C:34](=[O:35])[C:33]4[CH:37]=[C:38]([O:41][CH3:42])[CH:39]=[CH:40][C:32]=4[Br:31])[CH2:17][C:16]=3[CH2:15]2)=[CH:12][CH:13]=1)=[O:7]

Participants

5

Reactant 4

HCID 84468TrifluoroacetateHCID 899062-Bromo-5-methoxybenzoic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 67352824HCID 67352824, compound

Product 1

HCID 25105851HCID 25105851, compound

Procedure

N-(3-Hydroxypentyl)-6-(3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)pyridazine-3-carboxamide, trifluoroacetate (466 mg, 0.464 mmol) were reacted with 2-bromo-5-methoxybenzoic acid after activation with HATU analogously to example 3f. M+H+: 530.02.

Sources & evidence

ORD record
ord-fe83c18d192c41db936158474b0ee45b
Source dataset
uspto-grants-2011_08
Patent number
US08003677B2

Reaction notes

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