Trifluoroacetate → HCID 25105852, compound

HRID 1675363Notes

Reaction equation

HRID 1675363 reaction equation
[CH:1]1([CH2:4][CH2:5][NH:6][C:7]([C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][CH:14]=2)=[O:8])[CH2:3][CH2:2]1.[CH2:16]1[C:20]2[CH2:21][NH:22][CH2:23][C:19]=2[CH2:18][N:17]1[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[C:32]([F:35])([F:34])[F:33])=[O:25].FC(F)(F)C([O-])=O>>[CH:1]1([CH2:4][CH2:5][NH:6][C:7]([C:9]2[N:10]=[N:11][C:12]([N:22]3[CH2:23][C:19]4[CH2:18][N:17]([C:24](=[O:25])[C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=5[C:32]([F:34])([F:33])[F:35])[CH2:16][C:20]=4[CH2:21]3)=[CH:13][CH:14]=2)=[O:8])[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 84468TrifluoroacetateHCID 58075198HCID 58075198, compoundHCID 655615656-Chloro-N-(2-cyclopropylethyl)pyridazine-3-carboxamide

Product 1

HCID 25105852HCID 25105852, compoundYield 27%

Procedure

N-(2-Cyclopropylethyl)-6-chloropyridazine-3-carboxamide (150 mg, 0.665 mmol) and (3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)-(2-trifluoromethylphenyl)methanone, trifluoroacetate (263 mg, 0.665 mmol) were converted analogously to example 3b. Yield: 27%, M+H+: 472.08.

Sources & evidence

ORD record
ord-e932169d110b46bc802d436e9ffcf632
Source dataset
uspto-grants-2011_08
Patent number
US08003677B2

Reaction notes

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