HuagongsheHuagongshe Chemistry Print Report · For research reference only
C-Thiazol-4-yl-methylamine hydrochloride → N-Thiazol-4-ylmethyl-6-[5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo-[3,4-c]pyrrol-2-yl]nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | C-Thiazol-4-yl-methylamine hydrochloride | HCID 22467595 | — |
| Reactant | 6-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]nicotinic acid | HCID 58459784 | — |
| Product | N-Thiazol-4-ylmethyl-6-[5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo-[3,4-c]pyrrol-2-yl]nicotinamide | HCID 59360917 | 16% |
Reaction Steps
6-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]nicotinic acid (140 mg, 0.347 mmol) was reacted with C-thiazol-4-ylmethylamine, hydrochloride analogously to example 3d. Yield: 16%, M+H+: 500.40.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003677B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-7d66d72df2dc407882d1ce15860e3e09 |
| Source note | uspto-grants-2011_08 |