2-(Trifluoromethyl)benzoyl chloride → HCID 59360916, compound

HRID 1675368Notes

Reaction equation

HRID 1675368 reaction equation
FC(F)(F)C(O)=O.[CH:8]1([CH2:11][CH2:12][NH:13][C:14]([C:16]2[CH:17]=[N:18][C:19]([N:22]3[CH2:29][C:28]4[CH2:27][NH:26][CH2:25][C:24]=4[CH2:23]3)=[N:20][CH:21]=2)=[O:15])[CH2:10][CH2:9]1.[F:30][C:31]([F:42])([F:41])[C:32]1[CH:40]=[CH:39][CH:38]=[CH:37][C:33]=1[C:34](Cl)=[O:35]>>[CH:8]1([CH2:11][CH2:12][NH:13][C:14]([C:16]2[CH:17]=[N:18][C:19]([N:22]3[CH2:29][C:28]4[CH2:27][N:26]([C:34](=[O:35])[C:33]5[CH:37]=[CH:38][CH:39]=[CH:40][C:32]=5[C:31]([F:30])([F:41])[F:42])[CH2:25][C:24]=4[CH2:23]3)=[N:20][CH:21]=2)=[O:15])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 675612-(Trifluoromethyl)benzoyl chlorideHCID 86642240HCID 86642240, compound

Product 1

HCID 59360916HCID 59360916, compoundYield 23%

Procedure

N-(2-cyclopropylethyl)-2-(3,4,5,6-Tetrahydro-1H-pyrrolo-[3,4-c]pyrrol-2-yl)pyrimidine-5-carboxamide; compound with trifluoroacetic acid (300 mg, 0.726 mmol) was reacted with 2-trifluoromethylbenzoyl chloride analogously to example 3F. Yield: 23%, M+H+: 472.16.

Sources & evidence

ORD record
ord-17dc174be13d424a96a5acbbfa4c04f9
Source dataset
uspto-grants-2011_08
Patent number
US08003677B2

Reaction notes

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