Curcumin → Curcumin bis-methylsuccinate

Participants

Reaction Steps

To a solution of 3.68 g curcumin (10 mmole) in 20 ml tetrahydrofuran and 3 ml pyridine was slowly added at 0° C. a solution of 2.83 ml succinic acid monomethylesterchloride (23 mmole) in 5 ml of toluene. After stirring for 24 h at ambient, the reaction mixture was diluted with 100 ml acetic acid ethylester and washed with water. The organic phase was evaporated and the residue crystallised from ethyl acetate to yield 4.4 g curcumin-bis-methylsuccinate, m.p. 145-147° C.

Provenance & Evidence