Dicyclohexylcarbodiimide → HCID 86637944, compound

Participants

Reaction Steps

To a slurry of 1.85 g curcumin (5 mmole), 0.14 g 1-hydroxybenzotriazole (1 mmole) and 1.6 g N-formylaminobutyric acid in 5 ml pyridine and 50 ml dichloromethane was added 2.7 g dicyclohexylcarbodiimide (13 mmole). After stirring the mixture for 24 h at reflux, the solids were filtered off and washed thoroughly with dichloromethane. The filtrate was evaporated to yield 1.7 g curcumin-bis-formylaminobutyrate, m.p. 142-147° C. of approx. 80% purity.

Provenance & Evidence