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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1675416Generated: November 1, 2026

(2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid → (2S,4R)-tert-butyl 2-(N-(oct-6-enyl)-N-methylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylate

https://huagongshe.com/reaction/1675416

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acidHCID 688614—
Reactant(2S,4R)-tert-butyl 2-(N-(hex-5-enyl)-N-methyl-carbamoyl)-4-hydroxypyrrolidine-1-carboxylateHCID 57816706—
Reactantn-Methyloct-5-en-1-amine tosylate saltHCID 131729113—
Product(2S,4R)-tert-butyl 2-(N-(oct-6-enyl)-N-methylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylateHCID 66650516—

Reaction Steps

Compound 70b was synthesized from compound 32c and cis-N-Boc-4-hydroxy-L-proline as yellow oil in quantitative yield, following the procedure as described for compound 48.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08003659B2
Source datasetuspto-grants-2011_08
ORD IDord-8f6cdaa1f1fb4f0ca749a429c4642543
Source noteuspto-grants-2011_08