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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1675427Generated: October 31, 2026

3-(Trifluoromethyl)pyrazole → 7-methoxy-4-(4-methoxy-benzyloxy)-8-methyl-2-(3-trifluoromethyl-1H-pyrazol-1-yl)-quinoline

https://huagongshe.com/reaction/1675427

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)pyrazoleHCID 1807034—
Reactant2-Chloro-8-methyl-7-methoxy-4-(4-methoxy-benzyloxy)-quinolineHCID 56605159—
Product7-methoxy-4-(4-methoxy-benzyloxy)-8-methyl-2-(3-trifluoromethyl-1H-pyrazol-1-yl)-quinolineHCID 5660516019%

Reaction Steps

Compound 87c was synthesized from compounds 46b and 86a following the procedure as described for compound 86a, as a white solid in 19% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08003659B2
Source datasetuspto-grants-2011_08
ORD IDord-a4db2a7cac484dabbf77fc9ce9ddcfde
Source noteuspto-grants-2011_08