HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178487709, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Chloro-8-methyl-7-methoxy-4-(4-methoxy-benzyloxy)-quinoline | HCID 56605159 | — |
| Reactant | HCID 178439403 | HCID 178439403 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 178487709 | HCID 178487709 | 49% |
Reaction Steps
A solution of compound 86b (350 mg, 1 eq.) and compound 46b (480 mg, 6 eq.) in N-methylpyrrolidone (5 mL) was heated at 200° C. for 30 min. After the reaction mixture was cooled to room temperature, water was added. The mixture was extracted with EtOAc, dried over Na2SO4, filtered, and concentrated under reduced pressure. The crude material was purified by chromatography on silica gel (EtOAc/DCM). Recrystallisation in diethylether gave compound 88b as a white solid in 49% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003659B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-7643627824114f599057a7f2466ec571 |
| Source note | uspto-grants-2011_08 |