HRID1675436

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C

HCID2734883

N-tert-Butoxycarbonyl-L-hydroxyproline methyl ester

C11H19NO5

HCID86633208

未命名化合物

结构：COc1ccc2c(O)cc(-n3ccc(C(F)(F)F)n3)nc2c1Cl

HCID178487711

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@@H]1C[C@H](Oc2cc(-n3ccc(C(F)(F)F)n3)nc3c(Cl)c(OC)ccc23)CN1C(=O)OC(C)(C)C

HCID66650753

未命名化合物

收率 90%

PROCEDURE

实验过程

Compound 112 was synthesized from N-Boc-trans-4-hydroxy-L-proline-methyl ester 111 and compound 88a as beige foam in 90% yield, following the procedure as described for compound 54c.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9cc03b4b21124165a0584674378aeb58
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08003659B2
来源说明: uspto-grants-2011_08

反应 SMILES

[CH3:1][O:2][C:3](=[O:17])[C@@H:4]1[CH2:8][C@@H:7]([OH:9])[CH2:6][N:5]1[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11].[Cl:18][C:19]1[C:20]([O:39][CH3:40])=[CH:21][CH:22]=[C:23]2[C:28]=1[N:27]=[C:26]([N:29]1[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[N:30]1)[CH:25]=[C:24]2O.C(OC(C(CCC=CCCCCCCCCCC)CCC)=O)C>>[Cl:18][C:19]1[C:20]([O:39][CH3:40])=[CH:21][CH:22]=[C:23]2[C:28]=1[N:27]=[C:26]([N:29]1[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:35])[F:36])=[N:30]1)[CH:25]=[C:24]2[O:9][C@@H:7]1[CH2:6][N:5]([C:10]([O:12][C:13]([CH3:14])([CH3:16])[CH3:15])=[O:11])[C@H:4]([C:3]([O:2][CH3:1])=[O:17])[CH2:8]1