(1R,2S)-ethyl 1-((2S,4S)-4-(8-chloro-7-methoxy-2-(3-(trifluoromethyl)-1H-pyrazol-1-yl)quinolin-4-yloxy)-2-(hex-5-enyl(methyl)carbamoyl)pyrrolidine-1-carboxamido)-2-vinylcyclopropanecarboxylate → (1R,2S)-1-((2S,4S)-4-(8-chloro-7-methoxy-2-(3-(trifluoromethyl)-1H-pyrazol-1-yl)quinolin-4-yloxy)-2-(hex-5-enyl(methyl)carbamoyl)pyrrolidine-1-carboxamido)-2-vinylcyclopropanecarboxylic acid
Reaction equation
[Cl:1][C:2]1[C:3]([O:50][CH3:51])=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([N:12]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[N:13]1)[CH:8]=[C:7]2[O:21][C@@H:22]1[CH2:26][N:25]([C:27]([NH:29][C@:30]2([C:35]([O:37]CC)=[O:36])[CH2:32][C@H:31]2[CH:33]=[CH2:34])=[O:28])[C@H:24]([C:40](=[O:49])[N:41]([CH2:43][CH2:44][CH2:45][CH2:46][CH:47]=[CH2:48])[CH3:42])[CH2:23]1.CCCC(C(O)=O)CCC=CCCCCCCCCCC>>[Cl:1][C:2]1[C:3]([O:50][CH3:51])=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([N:12]1[CH:16]=[CH:15][C:14]([C:17]([F:19])([F:20])[F:18])=[N:13]1)[CH:8]=[C:7]2[O:21][C@@H:22]1[CH2:26][N:25]([C:27]([NH:29][C@:30]2([C:35]([OH:37])=[O:36])[CH2:32][C@H:31]2[CH:33]=[CH2:34])=[O:28])[C@H:24]([C:40](=[O:49])[N:41]([CH2:43][CH2:44][CH2:45][CH2:46][CH:47]=[CH2:48])[CH3:42])[CH2:23]1Participants
3
Reactant 2
Product 1
Procedure
Compound 117 was synthesized from compound 116 as a white solid in 60% yield, following the procedure as described for compound 55c.
Sources & evidence
- ORD record
- ord-d010a5b13d774954a91d0688e34c2e92
- Source dataset
- uspto-grants-2011_08
- Patent number
- US08003659B2
Reaction notes
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