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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1675454Generated: November 2, 2026

Ethyl 4-isopropylthiazole-2-carboxylate → 4-Cyclobutylthiazole-2-carboxylic acid ethyl ester

https://huagongshe.com/reaction/1675454

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 4-isopropylthiazole-2-carboxylateHCID 10821861—
Reactant2-ethoxy-2-thioxoAcetamideHCID 21613763—
Product4-Cyclobutylthiazole-2-carboxylic acid ethyl esterHCID 5370822664%

Reaction Steps

Compound V2 (yellow oil) was synthesized from compound U2 (23.87 g, 1 eq.) and ethyl thiooxamate (21.41 g, 1 eq.) in 64% yield, following the procedure as described for compound 36.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08003659B2
Source datasetuspto-grants-2011_08
ORD IDord-4adca2d78f484efe96cfabae12616940
Source noteuspto-grants-2011_08