Lithium Hydroxide → HCID 59273145, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of cyclopentyl (2S)-({-4-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}amino)(phenyl)acetate (Example 1) (50 mg, 102 μmol) in tetrahydrofuran (1 ml) was added 1.0M aq LiOH (0.508 ml, 508 μmol). The reaction was stirred at an oil bath temperature of 40° C. After 4 hours LCMS indicated 90% completion. The heating was removed and the reaction left to stir at room temperature overnight. The solvent was removed in vacuo and to the residue was added water (2 ml). 5 drops of acetic acid was added to the solution and a solid precipitated. The solid was collected by filtration and washed sequentially with water, ethanol and diethyl ether before drying under reduced pressure (26 mg, 60%).

Provenance & Evidence