Hydrochloric Acid → 3,5-Dimethoxy-4-[(prop-2-yn-1-yl)oxy]benzoic acid

Participants

Reaction Conditions

Reaction Steps

To 50 ml of methanol were added 15.5 g of 2-propynyl 4-(2-propynyloxy)-3,5-dimethoxybenzoate and 40 ml of a 15% aqueous sodium hydroxide solution, and the resulting mixture was stirred at 50° C. for 4 hours. Thereafter, the reaction mixture which had been allowed to cool to near room temperature was made acidic by addition of hydrochloric acid. The precipitated crystals were collected by filtration, and dried, and 13.0 g of 4-(2-propynyloxy)-3,5-dimethoxybenzoic acid was obtained.

Provenance & Evidence