Dimethylformamide → HCID 59301817, compound

Participants

Reaction Steps

To 50 ml of DMF were added 5.5 g of 4-hydroxy-3-fluorobenzoic acid, 9.4 g of propargyl bromide and 11 g of potassium carbonate, and the resulting mixture was stirred at room temperature for 8 hours. Thereafter, ethyl acetate was added to the reaction mixture, and this was filtered through Celite (registered trade mark). Water and dilute hydrochloric acid were successively added to the filtrate, followed by extraction with ethyl acetate. The organic layer was dried over magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, and 10.8 g of 2-propynyl 4-(2-propynyloxy)-3-fluorobenzoate was obtained.

Provenance & Evidence