反应详情

To 80 ml of acetonitrile were added 4.5 g of methyl 3,5-difluoro-4-hydroxybenzoate, 3.5 g of propargyl bromide and 9.4 g of cesium carbonate, and the resulting mixture was heated to reflux for 2 hours. Thereafter, the reaction mixture which had been allowed to cool to near room temperature was filtered through Celite (registered trade mark). The filtrate was concentrated under reduced pressure, and the residue was subjected to silica gel column chromatography, and 5.5 g of methyl 3,5-difluoro-4-(2-propynyloxy)benzoate was obtained.

1. temperaturethe resulting mixture was heated
2. temperatureto reflux for 2 hours
3. filtrationwas filtered through Celite (registered trade mark)
4. concentrationThe filtrate was concentrated under reduced pressure