Sodium Hydroxide → 3,5-Difluoro-4-(2-propynyloxy)benzoic acid

Participants

Reaction Steps

To 30 ml of ethanol were added 5.5 g of methyl 3,5-difluoro-4-(2-propynyloxy)benzoate and 10 ml of a 15% aqueous sodium hydroxide solution, and the resulting mixture was stirred at room temperature for 2 hours. Thereafter, the reaction mixture was concentrated under reduced pressure. Hydrochloric acid was added to the residue to make the mixture acidic, and the precipitated solids were collected by filtration, and 5.0 g of 3,5-difluoro-4-(2-propynyloxy)benzoic acid was obtained.

Provenance & Evidence