Acetonitrile → HCID 561417, compound

Participants

Reaction Steps

To 40 ml of acetonitrile were added 7.3 g of 3-fluoro-4-hydroxy-5-methoxybenzaldehyde, 8.8 g of benzyl bromide, 16.8 g of cesium carbonate and 10 ml of DMF, and the resulting mixture was heated under reflux for 10 hours. Thereafter, the reaction mixture which had been cool to near room temperature was concentrated under reduced pressure. Hydrochloric acid was added to the residue, followed by extraction with ethyl acetate. The organic layer was dried over magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, and 7.5 g of 4-benzyloxy-3-fluoro-5-methoxybenzaldehyde was obtained.

Provenance & Evidence