Water → HCID 57445724, compound

Participants

Reaction Steps

To a mixture of 200 ml of water and 6.8 g of potassium permanganate was added dropwise 7.5 g of 4-benzyloxy-3-fluoro-5-methoxybenzaldehyde dissolved in 200 ml of acetone at 15 to 20° C., and the resulting mixture was stirred at room temperature for 3 days. Thereafter, the reaction mixture was concentrated under reduced pressure to about half volume. To the concentrated solution were added an aqueous sodium hydrogen sulfite solution and dilute hydrochloric acid, followed by extraction with ethyl acetate. The organic layer was dried over magnesium sulfate, and concentrated under reduced pressure, and 4-benzyloxy-3-fluoro-5-methoxybenzoic acid was obtained.

Provenance & Evidence