Sodium Hydroxide → HCID 57445725, compound

Participants

Reaction Steps

To 40 ml of methanol were added 4.5 g of 2-propynyl 3-fluoro-5-methoxy-4-(2-propynyloxy)benzoate and 20 ml of a 15% aqueous sodium hydroxide solution, and the resulting mixture was stirred at room temperature for 8 hours. Thereafter, the reaction mixture was concentrated under reduced pressure. To the residue was added hydrochloric acid to make the mixture acidic. The precipitated solids were collected by filtration, and dried, and 3.7 g of 3-fluoro-5-methoxy-4-(2-propynyloxy)benzoic acid was obtained.

Provenance & Evidence