HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 1-(Benzyloxy)-2-bromo-4-(trifluoromethyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromo-4-(trifluoromethyl)phenol | HCID 2761168 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(Benzyloxy)-2-bromo-4-(trifluoromethyl)benzene | HCID 18782669 | — |
Reaction Steps
Benzyl bromide (21.4 ml) was added to a stirred mixture of 2-bromo-4-trifluoromethylphenol (46.4 g) and potassium carbonate (39 g) in DMF (200 ml). After 18 h, the mixture was partitioned between diethylether and water, the organic layer washed with water, 2M sodium hydroxide solution, water, dried and the solvent evaporated under reduced pressure. Yield 58.7 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003703B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-450f4d0e7c734ef586089492e8e3d60d |
| Source note | uspto-grants-2011_08 |