反应详情

温度

80 °C

A mixture of 2-benzyloxy-5-chlorophenylboronic acid (2.1 g), 3-cyanobenzyl bromide (1.57 g), sodium carbonate (1.7 g) and tetrakis(triphenylphosphine)palladium (0) (0.46 g) in ethylene glycol dimethyl ether (30 ml) was heated at 80° C. for 5 h. The mixture was cooled, partitioned between water/diethylether, the organics separated, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 5% ethylacetate/isohexane, yield 0.53 g.

1. temperatureThe mixture was cooled
2. custompartitioned between water/diethylether
3. customthe organics separated, dried
4. customevaporated under reduced pressure
5. customThe residue was purified by chromatography on silica eluting with 5% ethylacetate/isohexane, yield 0.53 g