Tetrahydrofuran → HCID 58775662, compound

Participants

Reaction Steps

Diisopropyl azodicarboxylate (0.14 ml) was added to a stirred solution of the product from example 56 step (ii) (0.2 g), triphenylphosphine (0.18 g), R-methyl lactate (0.1 g) in THF (10 ml). After 20 h, aqueous 1M sodium hydroxide solution (2 ml) was added and stirred for 4 h. The mixture was diluted with water (30 ml) then partitioned between ethyl acetate/2M hydrochloric acid. The organics were separated, washed with brine, dried and evaporated under reduced pressure. The residue was purified by RPHPLC, yield 0.094 g.

Provenance & Evidence