HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1675635Generated: October 31, 2026
Water → 4-Bromo-1-(methylthio)-2-(trifluoromethyl)-benzene
https://huagongshe.com/reaction/1675635
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 5-Bromo-2-fluorobenzotrifluoride | HCID 2736325 | — |
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Bromo-1-(methylthio)-2-(trifluoromethyl)-benzene | HCID 22315318 | — |
Reaction Steps
A mixture of sodium thiomethoxide (0.317 g) and 5-bromo-2-fluorobenzotrifluoride (1.0 g) in DMF (4 ml) was heated at 50° C. for 1 h then poured into water and extracted with isohexane. The organics were washed with brine, dried and evaporated under reduced pressure. Yield 0.762 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08003703B2 |
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| Source dataset | uspto-grants-2011_08 |
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| ORD ID | ord-be083e3818ab4c45b5fb996e950ff6c2 |
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| Source note | uspto-grants-2011_08 |
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