Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Quinoline-8-thiol hydrochloride | HCID 3082386 | — |
| Reactant | HCID 86034392 | HCID 86034392 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 58516136 | HCID 58516136 | — |
Reaction Steps
A mixture of the product from step (i) (0.262 g), 8-quinolinethiol hydrochloride (0.141 g), copper (1) iodide (7 mg), potassium carbonate (0.295 g) and ethylene glycol (0.08 ml) in iso-propanol (3 ml) was heated at 80° C. for 48 h. The mixture was partitioned between DCM/2M hydrochloric acid, the organics dried, evaporated under reduced pressure and the residue purified by chromatography on silica eluting with DCM:methanol:acetic acid (90:9:1). The residue was triturated with diethylether/methanol, filtered and dried, yield 0.101 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08003703B2 |
|---|
| Source dataset | uspto-grants-2011_08 |
|---|
| ORD ID | ord-8a9cf29b56d74c1a8a336d75cf50acce |
|---|
| Source note | uspto-grants-2011_08 |
|---|
