6-Amino-1-hexanol → HCID 24826555, compound

HRID 1675649Notes

Reaction equation

HRID 1675649 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:24])[CH2:11][CH2:12][CH2:13][C:14]([O:16]N2C(=O)CCC2=O)=O)=[CH:5][CH:4]=1)#[CH:2].[NH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][OH:32]>C(Cl)Cl>[OH:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][NH:25][C:14](=[O:16])[CH2:13][CH2:12][CH2:11][C:10]([NH:9][C:6]1[CH:5]=[CH:4][C:3]([C:1]#[CH:2])=[CH:8][CH:7]=1)=[O:24]

Participants

4

Reactant 2

HCID 199606-Amino-1-hexanolHCID 86619218HCID 86619218, compound

Product 1

HCID 24826555HCID 24826555, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of (2,5-dioxopyrrolidin-1-yl) 5-(4-ethynylphenyl)amino-5-oxo-pentanate (0.2 g, 0.6 mmol) in CH2Cl2 (10 ml) is added slowly to a solution of 1-amino-6-hexanol (0.35 g, 3.0 mmol) in CH2Cl2 (50 ml) with vigorous stirring. The crude reaction solution is concentrated by rotary evaporation and the mixture is purified by silica column chromatography (10% methanol/5% TEA/CH2Cl2).

Workup

  1. customThe crude reaction solution
  2. concentrationis concentrated by rotary evaporation
  3. customthe mixture is purified by silica column chromatography (10% methanol/5% TEA/CH2Cl2)

Sources & evidence

ORD record
ord-fe2f3234c51a4dcfaa419b87c6db0947
Source dataset
uspto-grants-2011_08
Patent number
US08003771B2

Reaction notes

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