HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo-4-chloroquinoline → (6-Bromoquinolin-4-yl)-[3-(tert-butyl-dimethylsilanyloxy)phenyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo-4-chloroquinoline | HCID 5139537 | — |
| Reactant | 3-((Tert-butyldimethylsilyl)oxy)aniline | HCID 14314782 | — |
| Product | (6-Bromoquinolin-4-yl)-[3-(tert-butyl-dimethylsilanyloxy)phenyl]amine | HCID 57857960 | 80.2% |
Reaction Steps
6.26 g (25.8 mmol) of 6-bromo-4-chloroquinoline are reacted by method A with 7.5 g (33.6 mmol) of 3-(tert-butyldimethylsilanyloxy)phenylamine. 8.9 g (20.7 mmol, 80%) of the desired product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003787B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-884f174bc6174d6c9dbd5a739790d11d |
| Source note | uspto-grants-2011_08 |