HCID 57857964, compound → HCID 25165463, compound

HRID 1675724Notes

Reaction equation

HRID 1675724 reaction equation
Cl.Br[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[NH:13][C:14]1[CH:15]=[C:16]([OH:22])[CH:17]=[C:18]([O:20][CH3:21])[CH:19]=1.[C:23]([NH:26][C:27]1[CH:28]=[C:29]([S:33]([CH3:36])(=[NH:35])=[O:34])[CH:30]=[CH:31][CH:32]=1)(=[O:25])[CH3:24]>>[OH:22][C:16]1[CH:15]=[C:14]([NH:13][C:6]2[C:5]3[C:10](=[CH:11][CH:12]=[C:3]([N:35]=[S:33]([C:29]4[CH:28]=[C:27]([NH:26][C:23](=[O:25])[CH3:24])[CH:32]=[CH:31][CH:30]=4)([CH3:36])=[O:34])[CH:4]=3)[N:9]=[CH:8][CH:7]=2)[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=1

Participants

3

Reactant 2

HCID 57857964HCID 57857964, compoundHCID 67351363HCID 67351363, compound2×

Product 1

HCID 25165463HCID 25165463, compound

Procedure

The title compound is prepared starting from 3-(6-bromoquinolin-4-ylamino)-5-methoxyphenol (intermediate 5) and S-(3-acetylaminophenyl)-S-methyl-sulphoximine in analogy to the synthesis of the compound of Example 17 (method D).

Sources & evidence

ORD record
ord-9cb8ef1d8af74a58829c29b308ec97a6
Source dataset
uspto-grants-2011_08
Patent number
US08003787B2

Reaction notes

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