2,4-Dibromo-1,3-thiazole → tert-Butyl [3-(4-bromo-1,3-thiazol-2-yl)-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]acetate

HRID 1675769Notes

Reaction equation

HRID 1675769 reaction equation
[O:1]=[C:2]1[N:6]([CH2:7][C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[C:5]2[CH:15]=[CH:16][CH:17]=[CH:18][C:4]=2[NH:3]1.Br[C:20]1[S:21][CH:22]=[C:23]([Br:25])[N:24]=1>>[C:11]([O:10][C:8](=[O:9])[CH2:7][N:6]1[C:5]2[CH:15]=[CH:16][CH:17]=[CH:18][C:4]=2[N:3]([C:20]2[S:21][CH:22]=[C:23]([Br:25])[N:24]=2)[C:2]1=[O:1])([CH3:14])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 27632972,4-Dibromo-1,3-thiazoleHCID 20814117Tert-butyl (2-oxo-2,3-dihydrobenzimidazol-1-yl)acetate

Product 1

HCID 86607786tert-Butyl [3-(4-bromo-1,3-thiazol-2-yl)-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]acetate

Procedure

Essentially following the procedures described for Intermediate 7, but using 2,4-dibromothiazole in place of 2-bromopyridine, the title compound was prepared. MS: m/z=412 (M+1).

Sources & evidence

ORD record
ord-6acccb0368a24a1d85dca39949e5571d
Source dataset
uspto-grants-2011_08
Patent number
US08003792B2

Reaction notes

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