1-Fluoro-2-nitrobenzene → HCID 18449410, compound

Participants

Reaction Steps

A solution of N,N-diisopropylethylamine (3.20 mL, 18.4 mmol), 1-fluoro-2-nitrobenzene (0.484 mL, 4.59 mmol), and (±)-tetrahydrofuran-3-amine (400 mg, 4.59 mmol) in n-butanol (10 mL) was heated to 180° C. in a microwave reactor. After 20 min, the reaction was allowed to cool to ambient temperature and concentrated. Purification by silica gel chromatography, eluting with a gradient of hexane:EtOAc-100:0 to 0:100, gave the title compound. MS: m/z=209 (M+1).

Provenance & Evidence