Hydrochloric Acid → 2-Bromo-6-iodopyridin-3-ol

Participants

Reaction Steps

To a solution of 2-bromo-3-hydroxypyridine (11-1, 28 g, 161 mmol) in water (360 mL) was added K2CO3 (22.24 g, 161 mmol) and I2 (20.42 g, 80 mmol). The system was stirred for 1.5 h at ambient temperature, cooled to 0° C. and then treated with concentrated HCl until solids precipitated from solution (pH˜6.0). The solids were isolated by filtration and dried to give the title compound (11-2) as a brown solid. ESI+MS C5H3BrINO: 299.8 found, 299.9 required.

Provenance & Evidence