HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl methyl ether → (2R)-6-Fluoro-3,4-dihydro-2-((2R)-2-oxiranyl)-2H-1-benzopyran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | (2R, 2'S)-6-Fluoro-2-(2'-oxiranyl)chromane | HCID 20575859 | — |
| Product | (2R)-6-Fluoro-3,4-dihydro-2-((2R)-2-oxiranyl)-2H-1-benzopyran | HCID 11356016 | 100% |
Reaction Steps
The resulting catalyst residue was dissolved in (2R)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-chromene (0.97 g), (2R)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene (0.97 g) [(R,R)-,(R,S)-epoxide diastereoisomeric mixture)] and MTBE (2.36 ml) and the mixture obtained was treated with H2O (0.099 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003810B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-1d76b385358d4110a70d34014b05bc9f |
| Source note | uspto-grants-2011_08 |