Water → Alendronate Sodium

Temperature

72 °C

A clear solution was prepared by dissolving 20 g of crude alendronate sodium in a solvent mixture containing 400 ml of water and 100 ml of methyl ethyl ketone by heating to reflux at temperature of about 72° C. with simultaneous stirring over a period of about 70 minutes. The solution was than filtered through cloth to make it free from particles, the filter was washed with 8 ml of water and the filtrate was transferred into another round bottom flask, subjected to cooling to a temperature of about 30° C. and than to 5° C. with simultaneous stirring for a period of about 90 minutes until the solid separated. The solid that was obtained was separated through filtration followed by washing with a mixture of 2 ml of methyl ethyl ketone and 4 ml of water and subjected to suction drying at a temperature of about 25° C. for a period of about 20 minutes. Then the obtained wet solid was finally subjected to drying in an oven by applying vacuum at about 100 millibarto afford 17 g (yield 85%) alendronate sodium trihydrate.

1. customA clear solution was prepared
2. temperatureby heating
3. filtrationthan filtered through cloth
4. washthe filter was washed with 8 ml of water
5. customthe filtrate was transferred into another round bottom flask
6. temperatureto cooling to a temperature of about 30° C. and than to 5° C.
7. stirringwith simultaneous stirring for a period of about 90 minutes until the solid
8. customseparated
9. customThe solid that was obtained
10. customwas separated through filtration
11. washby washing with a mixture of 2 ml of methyl ethyl ketone and 4 ml of water
12. customdrying at a temperature of about 25° C. for a period of about 20 minutes
13. customto drying in an oven

ORD record

ord-f62ea877f81e4aeca05b9c435f19569d

Source dataset

uspto-grants-2011_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08003820B2