HuagongsheHuagongshe Chemistry Print Report · For research reference only
ethyl 3-(5-amino-1H-benzimidazol-1-yl)-3-phenylpropanoate → 3-(5-Amino-1H-benzimidazol-1-yl)-3-phenylpropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | ethyl 3-(5-amino-1H-benzimidazol-1-yl)-3-phenylpropanoate | HCID 67351926 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-(5-Amino-1H-benzimidazol-1-yl)-3-phenylpropanoic acid | HCID 58653634 | — |
Reaction Steps
A solution of ethyl 3-(5-amino-1H-benzimidazol-1-yl)-3-phenylpropanoate (40 mg, 129 μmol) in hydrochloric acid (20 mL of a 5N solution) was stirred at room temperature for 72 hours. The solution was evaporated in vacuo and purified by RP-HPLC to afford the title compound, [LCMS (Method A, Mobile Phase II) RT=2.61 min, MH+ 282].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003806B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-11533ca94bc0432f9163fe03010c74e7 |
| Source note | uspto-grants-2011_08 |