HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-phenyl-3-[6-(trifluoromethyl)-1H-benzimidazol-1-yl]propanoate → 3-Phenyl-3-[6-(trifluoromethyl)-1H-benzimidazol-1-yl]propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-phenyl-3-[6-(trifluoromethyl)-1H-benzimidazol-1-yl]propanoate | HCID 67353239 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-Phenyl-3-[6-(trifluoromethyl)-1H-benzimidazol-1-yl]propanoic acid | HCID 11580810 | — |
Reaction Steps
A solution of ethyl 3-phenyl-3-[6-(trifluoromethyl)-1H-benzimidazol-1-yl]propanoate (74 mg, 204 μmol) in hydrochloric acid (10 mL of a 5N solution) was stirred at room temperature for 96 hours. The solution was evaporated in vacuo to afford the title compound, [LCMS (Method A, Mobile Phase II) RT=4.07 min, MH+ 335].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003806B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-cd220a921c64492fb0b51e5c10916dd1 |
| Source note | uspto-grants-2011_08 |