Ethyl 3-{5-[(4-nitrobenzoyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoate → 3-{5-[(4-Nitrobenzoyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoic acid

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Reaction Steps

A solution of ethyl 3-{5-[(4-nitrobenzoyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoate (60 mg, 131 μmol) in a mixture of acetonitrile (10 mL) and hydrochloric acid (20 mL of a 5N solution) was stirred at room temperature for 72 hours. The resulting precipitate was collected by filtration, and air-dried to afford the title compound, [LCMS (Method A, Mobile Phase II) RT=3.84 min, MH+ 431].

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