HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-{5-[(3-nitrobenzoyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoate → 3-{5-[(3-Nitrobenzoyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-{5-[(3-nitrobenzoyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoate | HCID 58653703 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-{5-[(3-Nitrobenzoyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoic acid | HCID 11553743 | — |
Reaction Steps
A solution of ethyl 3-{5-[(3-nitrobenzoyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoate (40 mg, 87 μmol) in hydrochloric acid (20 mL of a 5N solution) was stirred at room temperature for 110 hours. The solution was then evaporated in vacuo, and purified by RP-HPLC to give the title compound, [LCMS (Method A, Mobile Phase II) RT=3.91 min, MH+ 431].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003806B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-5eae6da8c5764cb8899b0ca5a0a824e5 |
| Source note | uspto-grants-2011_08 |