HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 3-{6-[(2-aminobenzoyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Methyl 3-{6-[(anilinocarbonyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoate | HCID 58653678 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-{6-[(2-aminobenzoyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoic acid | HCID 11611040 | — |
| Product | 3-{6-[(Anilinocarbonyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoic acid | HCID 58653683 | — |
Reaction Steps
A solution of methyl 3-{6-[(anilinocarbonyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoate (90 mg, 210 μmol) in a mixture of hydrochloric acid (20 mL of a 5N solution) and acetonitrile (10 mL) was stirred at room temperature for 72 hours. The solution was evaporated in vacuo to afford the title compound, [LCMS (Method A, Mobile Phase II) RT=3.77 min, MH+ 401].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003806B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-2b5dcf0a029042fb8b091ba3a8e4c9f2 |
| Source note | uspto-grants-2011_08 |