3-Bromo-2,6-dimethoxybenzoic acid → HCID 11511998, compound

HRID 1676074Notes

Reaction equation

HRID 1676074 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[CH:8][N:7]([CH:10]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:11][C:12]([O:14]CC)=[O:13])[C:6]=2[CH:23]=1.[Br:24][C:25]1[C:26]([O:36][CH3:37])=[C:27]([C:31]([O:34][CH3:35])=[CH:32][CH:33]=1)[C:28]([OH:30])=O>>[Br:24][C:25]1[C:26]([O:36][CH3:37])=[C:27]([C:31]([O:34][CH3:35])=[CH:32][CH:33]=1)[C:28]([NH:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[CH:8][N:7]([CH:10]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:11][C:12]([OH:14])=[O:13])[C:6]=2[CH:23]=1)=[O:30]

Participants

3

Reactant 2

HCID 27747443-Bromo-2,6-dimethoxybenzoic acidHCID 67351765ethyl 3-(6-amino-1H-benzimidazol-1-yl)-3-phenylpropanoate

Product 1

HCID 11511998HCID 11511998, compound

Procedure

Using the procedure of Preparation 21, the title compound (24 mg) was prepared from ethyl 3-(6-amino-1H-benzimidazol-1-yl)-3-phenylpropanoate and 3-bromo-2,6-dimethoxybenzoic acid, and purified by RP-HPLC. [LCMS (Method A, Mobile Phase I) RT=4.43 min, MH+ 526].

Workup

  1. customthe procedure of Preparation 21
  2. custompurified by RP-HPLC

Sources & evidence

ORD record
ord-191d65d347ab409da0baca2c2c98addf
Source dataset
uspto-grants-2011_08
Patent number
US08003806B2

Reaction notes

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