Benzoic acid, 2,3,5-trichloro-6-hydroxy- → HCID 11699053, compound

HRID 1676075Notes

Reaction equation

HRID 1676075 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[CH:8][N:7]([CH:10]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:11][C:12]([O:14]CC)=[O:13])[C:6]=2[CH:23]=1.[Cl:24][C:25]1[CH:33]=[C:32]([Cl:34])[C:31]([Cl:35])=[C:27]([C:28](O)=[O:29])[C:26]=1[OH:36]>>[C:17]1([CH:10]([N:7]2[C:6]3[CH:23]=[C:2]([NH:1][C:28](=[O:29])[C:27]4[C:26]([OH:36])=[C:25]([Cl:24])[CH:33]=[C:32]([Cl:34])[C:31]=4[Cl:35])[CH:3]=[CH:4][C:5]=3[N:9]=[CH:8]2)[CH2:11][C:12]([OH:14])=[O:13])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 94511Benzoic acid, 2,3,5-trichloro-6-hydroxy-HCID 67351765ethyl 3-(6-amino-1H-benzimidazol-1-yl)-3-phenylpropanoate

Product 1

HCID 11699053HCID 11699053, compound

Procedure

Using a similar procedure to that described in Preparation 21, the title compound (19 mg) was prepared from ethyl 3-(6-amino-1H-benzimidazol-1-yl)-3-phenylpropanoate and 3,5,6-trichlorosalicylic acid (HATU was substituted for TBTU), and purified by RP-HPLC. [LCMS (Method A, Mobile Phase I) RT=4.54 min, MH+ 506].

Workup

  1. customthat described in Preparation 21
  2. custompurified by RP-HPLC

Sources & evidence

ORD record
ord-592d093081cc419f81f37458cce49650
Source dataset
uspto-grants-2011_08
Patent number
US08003806B2

Reaction notes

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