Ammonium formate → HCID 58653652, compound

Participants

Reaction Steps

To a solution of methyl (3R)-3-(2,4-dinitroanilino)-3-phenylpropanoate (3.14 g, 9.1 mmol) in a mixture of ethanol (100 mL) and water (10 mL) was added ammonium formate (2.3 g, 36 mmol) and palladium on carbon (300 mg, 10% w/w Pd). The mixture was stirred at room temperature for 2 hours, then filtered through a pad of Celite®, evaporated in vacuo. The residue was purified by flash column chromatography on silica gel, eluting with a mixture of dichloromethane and methanol (95:5), to afford the title compound, [LCMS (Method C, Mobile Phase I) RT=2.94 mins, MH+ 316].

Provenance & Evidence