反应详情

To a solution of methyl 3-(2-amino-4-nitroanilino)-3-(1,1′-biphenyl)-4-ylpropanoate (60 mg, 153 μmol) in 2-ethoxyethanol (1 mL) was added formamidine acetate (48 mg, 461 μmol). The solution was heated to reflux for 6 hours, then cooled to room temperature, and evaporated in vacuo. The residue was purified by flash column chromatography on silica gel, eluting with dichloromethane, to afford the title compound, [LCMS (Method A, Mobile Phase I) RT=6.11 min, MH+ 402].

1. temperatureThe solution was heated
2. temperatureto reflux for 6 hours
3. customevaporated in vacuo
4. customThe residue was purified by flash column chromatography on silica gel
5. washeluting with dichloromethane