4-Isobutyl-3,5-dimethylthiophene-2-carboxylic acid → 2,6-Diethyl-4-[5-(4-isobutyl-3,5-dimethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenol
Reaction equation
[CH2:1]([C:5]1[C:6]([CH3:14])=[C:7]([C:11]([OH:13])=O)[S:8][C:9]=1[CH3:10])[CH:2]([CH3:4])[CH3:3].[OH:15][C:16]1[C:25]([CH2:26][CH3:27])=[CH:24][C:19]([C:20]([NH:22]O)=[NH:21])=[CH:18][C:17]=1[CH2:28][CH3:29]>>[CH2:28]([C:17]1[CH:18]=[C:19]([C:20]2[N:22]=[C:11]([C:7]3[S:8][C:9]([CH3:10])=[C:5]([CH2:1][CH:2]([CH3:3])[CH3:4])[C:6]=3[CH3:14])[O:13][N:21]=2)[CH:24]=[C:25]([CH2:26][CH3:27])[C:16]=1[OH:15])[CH3:29]Participants
3
Procedure
2,6-Diethyl-4-[5-(4-isobutyl-3,5-dimethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenol is prepared from 4-isobutyl-3,5-dimethyl-thiophene-2-carboxylic acid and 4,N-dihydroxy-3,5-diethyl-benzamidine in analogy to Example 21; LC-MS: tR=1.24 min, [M+1]=385.28.
Sources & evidence
- ORD record
- ord-80c2dc75ca4944ef88570acfcf027beb
- Source dataset
- uspto-grants-2011_08
- Patent number
- US08003800B2
Reaction notes
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