HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine → 5-phenyl-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine | HCID 4184869 | — |
| Reactant | 4-Hydroxy-5-phenylpyridin-2(1H)-one | HCID 54683258 | — |
| Reactant | 4-(Methylsulfonyl)pyridin-2(1H)-one | HCID 55296580 | — |
| Reactant | 5-Propylpyrimidin-2-ylpiperidin-4-yl methanesulfonate | HCID 86626267 | — |
| Product | 5-phenyl-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one | HCID 67369617 | — |
Reaction Steps
The compound in Step C was prepared according to the procedures described in Example 1 substituting 4-hydroxy-5-phenylpyridin-2(1H)-one for 4-hydroxy-1-(4-(methylsulfonyl)pyridine-2(1H)-one and 1-(5-propylpyrimidin-2-yl)piperidin-4-yl methanesulfonate for tert-butyl 4-(methylsulfonyloxy)piperidine-1-carboxylate in Step D. MS (ESI) 391 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003796B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-661f1973914040b995f0746001300e25 |
| Source note | uspto-grants-2011_08 |