2-Morpholinoethylamine → N1-(3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenyl)-N2-(2-morpholinoethyl)oxalamide

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Reaction Steps

Ethyl 2-(3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylamino)-2-oxoacetate (prepared in Example 2; 36 mg, 0.10 mmol) and 2-morpholinoethanamine (65 mg, 0.50 mmol) were heated to 60° C. for 18 hours. The mixture was diluted with diethyl ether (1 mL) and filtered. The white solid was washed with diethyl ether (3×2 mL). The solid was dried under high vacuum. The product was obtained as a white powder (17 mg, 38%). 1H NMR (400 MHz, CDCl3) δ 9.50 (s, 1H), 8.52 (d, J=6 Hz, 1H), 7.99 (m, 1H), 7.87 (m, 1H), 7.76 (d, J=6 Hz, 1H), 7.58 (d, J=6 Hz, 1H), 7.41 (m, 1H), 7.29 (m, 1H), 6.52 (d, J=6 Hz, 1H), 3.74 (m, 4H), 3.49 (m, 2H), 2.59 (m, 2H), 2.50 (m, 4H). LRMS (ESI pos) m/e 445 (M+1). HPLC: 100% purity (220 nm).

Provenance & Evidence